Takayasu arteritis

Takayasu arteritis is a rare type of vasculitis that causes inflammation and stenozarea aorta and its branches, also called aortic arch syndrome.In 1908 ophthalmologist Takayasu Mikito vessel reported eye changes to a Japanese woman for 21 years.Takayasu arteritis is a rare, inflammatory, affecting women in the percentage increased from 20 to 30 years. There is no disease called peripheral pulse because the pulse can be difficult because of destruction detectable arterial walls.
The disease is characterized by many symptoms of chronic ischemia due to thrombus formation and stenozarii aorta, such as blindness, cataracts, retinal bleeding, absence of peripheral pulse, regurcitare aortic dilatation and congestive heart failure through the aortic wall lesions cause disease ascendente.Progresia finally to arterial aneurysms carrying dissected.
The etiology of this disease is necunoscuta.Pacientii are mostly women of Asian and Latin American countries.
The disease is variable and may occur spontane.Datele remission statistics show a mortality up to 75%. Combination of corticosteroid therapy for signs and symptoms of acute and aggressive approach, surgery and angioplasty of stenosed vessels improved survival and mortality scazur.
PathophysiologyThe disease affects large and medium arteries, mostly branches of the aorta and aortic branches sale.Implicarea is significant in emerging than distal. Histology is present panarterita with occasional mononuclear cell infiltration and cell proliferation gigante.Exista intimate marked fibrosis, scarring and vascularization media and lamina fragmentation and degeneration of lumen narrowing occurs elastice.Astfel, with or without fibrosis.
CausesIt is not known exactly what causes Takayasu arteritis, some researchers believe the involvement of infections such as tuberculosis could be a declansa.O Another theory is that the disease is a dysfunction of the immune system.