Basal cell carcinoma

Basal cell carcinoma is the most common cancer in humans. Appears in the areas of chronic sun exposure. It has a slow and rarely metastasize but can cause clinically significant loala destruction and defacement if neglected or treated inappropriately. The prognosis is excellent with proper therapy.
Patients often have an ulcer that will not heal. The lesion appears on the face, scalp, neck or upper trunk. Trauma determine its easy bleeding. Basal cell carcinoma cause significant morbidity if she is allowed to progress. Because this cancer affects more than the head and neck is associated with cosmetic disfigurement. Loss of vision or eye damage can occur in orbit. Perineural extension may lead to loss of nerve function and enlargement of the tumor deep. These neoplasms are often brittle and prone to ulceration and therefore allow infection. Death by basal cell carcinoma is very rare.
Local therapy with chemotherapeutic and immunomodulatory agents is useful in cases of basal cell carcinoma. Small and superficial lesions usually respond to them. In addition can be used for prophylaxis and maintenance in patients prone to many carcinomas, such as those in basal cell nevus syndrome.Surgical treatment follows the destruction or removal of the tumor to prevent tumor tissue to proliferate. Most common method is surgical curettage, marginal excision with examination, Mohs micrographic surgery and radiotherapy. Occasionally radiation therapy is used to treat these tumors.
Incompletely treated basal cell carcinoma can recur. All treated areas should be monitored soup therapy. Persons with basal cell carcinoma were 30% risk of developing another carcinoma not associated with previous injury risk compared with the general population. Is encouraged to avoid sun exposure, avoiding environmental activities in the open between 10 am. 00 and 16. 00 and encouraged the use of sunscreen with a factor of over 30.
The pathogenesis of basal cell carcinoma
Many researchers believe that cells derived from basal cell carcinoma pluripotentiale basal layer of the epidermis or follicular structures. These cells form continuously during life and can develop hair follicles, sebaceous glands and apocrine glands. Tumors develop from the epidermis and occasionally a hair root. Ultraviolet induced mutations in tumor suppressor genes.
Causes and Risk Factors
Ultraviolet radiation is the most important and common causes of basal cell carcinoma. Short waves band plays an important role in the formation of carcinoma from the UV-A. In addition, chronic sun exposure appears to be important in the development of basal cell carcinoma. A latent period of 20-50 years is typical in the ultraviolet damage and clinical onset of carcinoma.
Chronic exposure to arsenic is associated with the development of basal cell carcinoma. Exposure can be medicine, occupational or dietary. A contaminated water is the most common cause.
Immunosuppression is associated with a modest increase in risk of basal cell carciomului.
Xeroderma pigmentosum is an autosomal recessive disorder that predisposes to the rapid aging of the skin exposed to sunlight, starting with pigmentary changes and progression of basal cell carcinoma, squamous cell carcinoma and malignant melanoma. The effects are due to inability to repair DNA alterations induced by the sun. Other features include corneal opacity, blindness and neurological deficits.
Basal cell nevus syndrome (Gorlin syndrome, nevoid basal cell carcinoma syndrome) shows the appearance of multiple basal cell carcinoma in autosomal dominant ways, with onset at a young age. It is associated with odontogenic keratochisti, calcifications and abnormalities palmoplantare coast. Different tumors can occur as medulloblastoma, meningiomas, and fetal rabdomiomul ameloblastomul.
Bazex syndrome is an X-linked dominant condition with follicular atrofodrma marks ("ice" especially on the dorsal hands, multiple basal cell carcinomas, local anhidrosis (lack of sweating) and congenital hipotrichoza.
Rombo syndrome is an autosomal dominant condition characterized by basal cell carcinomas and atrofoderma vermiculatum, trichoepitelioame, hipotrichozis milia and peripheral vasodilation with cyanosis.
History of nonmelanoma skin cancer: people with one nonmelanoma skin cancers are at increased risk of developing more in the future. The rate of developing new skin cancers is 35% at 3 years and 50% at 5 years after initial diagnosis of cancer.

Skin Allergies

Skin AllergiesTop 10 causes of skin allergiesWhen contact with a specific substance (allergen) causes a skin allergy, talk about allergic contact dermatitis. This inflammatory disease can have devastating consequences on the lives of patients.Contact dermatitis can affect the skin all over his body on some parts. If it locates on the hands and feet, the disease may prevent patients to practice their profession.Skin tests are used to identify substances that trigger allergic reaction. These tests consist in applying a patch on the skin that are placed on low doses of common allergens.Top 10 substances which cause allergic reactions are:EO Nickel (nickel sulfate hexahydrate) - metal utilized in the manufacture of jewelry, buckles, or buttons.EO Gold, of precious metal that is found commonly in jewelry.EO Balsam of Peru-aromatic substance used in perfumes and skin lotions, derived from a tree resin.EO Thiomersal mercury-containing substance, found in local antiseptics and is used as a preservative in some vaccines.EO-antibiotic neomycin sulfate used in creams and ointments, and occasionally in cosmetics, deodorants, soap and pet food.EO-flavors found in foods, cosmetics, insecticides, antiseptics, soaps, perfumes and dental materials.EO-formaldehyde preservative with multiple uses: stationery products, hygienic and cosmetics, paints and farmaceutică industry.EO-metal cobalt chloride farmaceutică used in industry, the manufacture of hair dyes, antiperspirants, clad with metal objects (buttons, zippers, etc.).EO Whereas bacitracin topical antibiotic.EO-15 Quaternium-preservative that releases formaldehyde and is found in cosmetics (nail polish, lotion, beach, foundation, powder, concealer, mascara, bronzer, cleanser), in pharmaceutical or personal care products (shampoo, soap, creams and lotions, shaving products, disinfectants) and industrial chemicals (adhesives, polishes, waxes and varnishes, paper and cardboard, latex paint, etc.).

 If a skin test result is positive, avoid substance by the patients. Therapy or corticosteroid cream may be helpful, although 3% of patients have allergic reactions to these creams.

Skin care for women

Few of us can boast a flawless complexion, left to nature or God .... Most of us complain: why have oily skin when he was dry, why we have land where we had more normal .... We are strict and may therefore we are often dissatisfied with ...
But we have a beautiful, bright and a fresh face if we know exactly what type of skin we have, what we offer him to thank the casting an eye in the mirror: be expensive cosmetics, fine, with caviar and gold dust, be the usual natural ingredients from the market or garden suite.
A ritual correct skin care, cleaning and removing the morning but the evening, use of toners, an age-appropriate creams and skin type is key to obtain a chip with a few years younger than the age of the bulletin.
Loading with makeup on, as black as coloring the lips up to stem the eye, short or longer to taste the products of questionable quality, maturity give us that many of us want it to youth, but then we give youth Jindu later.What about makeup and what is right and we talk once stated ... We start from the skin and is our guy ...
Classic describes four types of skin, each with its own characteristics and the way of proper care.

    * Normal skin - not greasy nor dry, bright, radiant health. The amount of water and fat are balanced, the pores are less visible, little or no impurities ... um ... too good to be true. You are right. It is most frequently encountered type of skin. Happy those who have it.
Normal Skin CareCleaning will be done with a liquid cream, delicate, it will then use a toner and a moisturizer.
Refreshing mask for normal skin: small cucumber, finely chop and mix with half a glass of fresh yogurt. The resulting paste is applied on face for 5-10 minutes and remove with water.

    * Dry skin - hydration is poor, and sebaceous glands do not produce enough fat to keep the skin lubricated. Wrinkles are more visible expression of this type of skin aging faster than normal and oily skin.
Dry skin careCleansing with a product in the form of creams, toners without alcohol content, regular facial massage, moisturizer and an appropriate amount of water consumption.
Milk and Honey Moisturizing Mask: Mix 2 tablespoons honey and 2 tablespoons of milk and spread mixture on face and neck. Leave on for 10 minutes, then rinse with warm water.

    * Oily skin - looks shiny and is prone to the appearance of pimples and blackheads, pores are often enlarged and dilations or allergies can occur. The area most affected is the area T, which comprises the central part of the forehead, nose and chin. However, oily skin, retains a younger look with the passage of time than other types.
Oily skin careHe needs daily cleaning to prevent accumulation of dirt. Warning however: excessive cleaning of the skin can stimulate the skin to produce more fat.
Mask in March to reduce pore March to shave a half after the seeds were removed, combined with a tablespoon of honey, spreads on the face and let it act for 20 minutes.

    * Combination skin - very common, is a mix between the dry and oily skin, a part of the face shows oily "T zone" and the rest - dry skin.
Joint Skin CareThis skin type requires different treatments, using products for every skin type.