Juvenile chronic arthritis Treatment

Juvenile chronic arthritis

    * Introduction
    * Symptoms and Diagnosis
    * Differential Diagnosis
    * Treatment
back Treatment
Juvenile chronic arthritis therapy is for life because of severe complications occurring in the disease. Thus, we can form definite ankylosis stopping growth. In this respect it is leg extension, if it is in flexion.
TREATMENT systemic forms of step-up benefits (more and stronger medication). It is administered anti-inflammatory drugs (NSAIDs) in the first line. Their effect is to inhibit prostaglandin - synthase, the enzyme that catabolizeaza arachidonic acid to form lipid mediators plus plus prostaglandin and thromboxane in the presence of COX-1 COX-2. Drug therapy is oral: 5-10mg/kgc phenylbutazone, ibuprofen, diclofenac 1-3mg/kgc (Voltaren), oxicam: 2mg/kgc piroxicam (Feldene). Some NSAIDs are administered second-line D-penicillamine (CUPRENIL) SALAZOPIRINA (5 acetyl salicylic acid derivative) at a dose of 300-600mg/zi, gold salts, but bone marrow toxicity. Intended effects appear after 6 weeks, during which the doses are gradually increased. It also found numerous adverse effects. Third-line anti-inflammatory drugs are also known as corticosteroids. Among these may be given: Prednisone, used first in forms and in the systemic pauciarticulare with iridocyclitis; DEXAMENTAZONA, BETAMEZON, methylprednisolone, immunosuppressants used in a series of short courses of 2-3 weeks: Azithromycin (Imuran), methotrexate, cyclophosphamide , cyclosporine (rare). Immunosuppressants can be associated with infliximab (antibody Monoclonal anti-TNF) in de3-10mg/kgc/sapt dose., intra-venous infusion of at least 3 months. It also may be associated with etanercept, an inhibitor of tumor necrosis factor receptor (TNF) at a dose of 0. 2 times per week 4mg/kgc sub-skin for 7 months. The latter two drugs are used in severe forms of inflammation, systemic and polyarticular rheumatoid factor positive.
Coxibs is a group of drugs accounted Aulin our market. It acts selectively on the COX 1 and COX-2 and is given, usually after age 12.
From belts and Balneophysiotherapy drugs is especially acute when normalized phase reactants (ESR normal) and to maintain joint mobility. It required special attention to position. It stressed that etse joint function can be maintained for a longer time.
Antalgicele muscle relaxant medication and therapy is associated in all forms of disease.
Admin drugs is: by systemic and intraarticular, such as anti-inflammatory drugs (NSAIDs) and anti-inflammatory steroid (AIS) if there are joints that do not improve the systemic administration.
In juvenile chronic arthritis (JCA) ankylosis occur definitive surgical correction is therefore needed, or prosthetics. Juvenile chronic arthritis is growing, unlike rheumatic fever (RAA) which is continuously decreasing.