There are three current theories on the pathogenesis of migraine.
The first component refers to the vasomotor theory.
In patients with classic migraine during attacks there is a moderatereduction in cortical blood flow in the visual cortex that startsexpanding at a rate of 2-3 mm / min. Cortical hypoperfusion cause a reduction in cerebral blood flow by 25-30% and may persist for4-6 hours.
Subcortical structures, but remains normal perfusion. Waveoccipital hypoperfusion extends to the frontal area as theheadache phase starts. There are few patients with classicmigraine that will not flow abnormalities.
A second theory relates to the projections of serotonergic anddorsal cord. Involvement of serotonin neurons in the mechanism ofmigraine was suggested by the beneficial results obtained aftertreatment with sumatriptan and metisergid.
Rafe back is involved in migraine generation, being located at thislevel the highest number of receptors for serotonin and is the site of action of antimigraine drugs.
A third theory takes into account the trigeminal vascular system.Cells in the caudal trigeminal nucleus of the bulb producevasoactive neuropeptides that are released in the trigeminal nerveendings, vascular, inducing a sterile inflammation, swelling of softtissue pain and enhances the distribution of nerve V.
The first component refers to the vasomotor theory.
In patients with classic migraine during attacks there is a moderatereduction in cortical blood flow in the visual cortex that startsexpanding at a rate of 2-3 mm / min. Cortical hypoperfusion cause a reduction in cerebral blood flow by 25-30% and may persist for4-6 hours.
Subcortical structures, but remains normal perfusion. Waveoccipital hypoperfusion extends to the frontal area as theheadache phase starts. There are few patients with classicmigraine that will not flow abnormalities.
A second theory relates to the projections of serotonergic anddorsal cord. Involvement of serotonin neurons in the mechanism ofmigraine was suggested by the beneficial results obtained aftertreatment with sumatriptan and metisergid.
Rafe back is involved in migraine generation, being located at thislevel the highest number of receptors for serotonin and is the site of action of antimigraine drugs.
A third theory takes into account the trigeminal vascular system.Cells in the caudal trigeminal nucleus of the bulb producevasoactive neuropeptides that are released in the trigeminal nerveendings, vascular, inducing a sterile inflammation, swelling of softtissue pain and enhances the distribution of nerve V.
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