Tuesday, May 24, 2011

Osteomalacia - Diagnosis

Laboratory studies:
demonstrates the deficiency of vitamin D
evaluate the liver function, kidney function
evaluate the serum calcium and phosphate, serum alkalinephosphatase is low
, parathyroid hormone is increased.

Imaging Studies:
Osteomalacia in patients with X-ray shows only osteopenia.However this feature is disorganized trabeculae. Complicationssuch as areas of bone loss and fractures can be observedradiographically complete. Items include radiographic renalosteodystrophy bone resorption, soft tissue calcifications,osteopenia, and fractures of amyloid deposit.
Conputerizata tomography scan assess pathological fractures.Amyloidosis may cause erosion in and around a joint.
Bone scintigraphy showed diffuse radionuclide skeletal abstractionthat can be confused with metastatic disease. However extremitiesshows a high gaining secondary hyperparathyroidism comparedwith metastatic disease. In addition, bone scans showing areas ofcalcification or skeletal pseudofracturi.
The differential diagnosis is made ​​with the following diseases:rickets, hyperparathyroidism, multiple myeloma, rheumatoidarthritis, malabsorption syndrome, storage disease calciumpyrophosphate.

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