Squamous cell carcinoma Signs and symptoms

Squamous cell carcinoma
Signs and symptoms
Age of presentation is 70 years, though it varies, and in certain high risk groups squamous cell carcinoma may occur at younger ages. Squamous cell carcinoma typically manifests itself through a new skin lesion or enlargement of existing lesions are concerned about the patient. It is a slow-growing cancer, but some lesions can enlarge rapidly. Although most patients are asymptomatic, symptoms such as bleeding, scaling, pain or tenderness can note, especially in large tumors. Paresthesias, muscle weakness and impaired treorul indicate perineural.
Squamous cell carcinoma derived from actinic lesions. It is the most common type of squamous cell carcinoma of sun-induced one. It is frequently noted a history of sun exposure in childhood. Many patients report multiple sunburns and other psoralen and ultraviolet A therapy or artificial tanning solarium.
Immunosuppression. Patients should ask about possible sources of immunosuppression. The historical notes in solid organ transplantation, hematologic malignancies (chronic lymphocytic leukemia, HIV infection, long-term immunosuppressive therapy).
Marjolin ulcer. This eponym refers to squamous cell carcinoma arises out of a chronically inflamed skin and scarring. Patients may report the change of the skin: induration, elevation, ulceration) have scars at a pre-existing lesions. Latent period is 20-30 years.
Squamous cell carcinoma associated with HIV. Squamous cell carcinoma induced viral warts manifest printrun new or expands on the penis, vulva or perianal area, periunghiala region. Patients presenting with a history of warts resistant to treatment.
Physical Exam
Squamous cell carcinoma can occur through a variety of morphologies with or without associated symptoms.
Squamous cell carcinoma in situ. It is defined histologically by atypical but without involving the entire thickness of the epidermis, dermis invasion. Clinical lesions vary from a pink stain with scaling up to a fine or similar card papule keratosis Actinic keratosis. Bowen's disease is a subtype of squamous cell carcinoma in situ characterized by the appearance of a well-demarcated pink tiles on non-sun-exposed skin. Eritroplazia Queyart of Bowen's disease refers to the penis which is manifested by one or more cards to soft pink.
Typical squamous cell carcinoma. Invasive squamous cell carcinoma is a pink papule or plaque, keratosis, farm, high occurs on sun-exposed skin. Approximately 70% of all squamous carcinomas and it appear on the head, upper extremities 15%. Surface modification includes scaling, ulceration, crustificarea or presence of a cutaneous horn. Less commonly, squamous cell carcinoma manifests as a pink skin nodule without surface modification. The absence of surface changes should raise the suspicion of a metastasis from another location or noncutanata or skin tumors and Merkel cell carcinoma is the deadliest. It is also noted altered skin solar solar elastosis, skin, teleangiectaziile, multiple actinic keratoses.
Periunghial squamous cell carcinoma. It mimics a typical wart and is frequently misdiagnosed for years as a wart. Less commonly, lesions may show chronic paronychia swelling, redness and sensitivity nail onicodistrofie.
Marjolin ulcer. This subtype of squamous cell carcinoma appears as a new area of induration, elevation or ulceration at the site of a pre-existing scars have ulcers. The diagnosis should be considered for any ulcer that will not heal with therapy.
Perioral squamous cell carcinoma. Squamous cell carcinoma of the lip occurs on the skin of the lower lip. It is preceded by a precursor lesion, actinic Cheilitis which manifests as xerosis, with cracking, atrophy and depigmentation. Actinic Cheilitis Actinic keratosis is a skin analog. Lip squamous cell carcinoma manifests as a papule, erosion or local erythema and induration. Intraoral carcinoma manifests as a white-board with or without crosslinking leucoplakie red-eritroplakie. Common localizations above includes floor of the mouth, lateral tongue and buccal vestibule.
Anogenital squamous cell carcinoma. Squamous cell carcinoma of the anogenital region is manifest as a wet plate, the glans penis red, indurated or ulcerated lesion on the vulva, anus, scrotum or external. Associated symptoms include pain, itching, bleeding intermittently.
Carcinoma warts. It is a subtype of squamous cell carcinoma can be locally destructive but rarely metastasize. Lesions appear as a nodule or plaque, exofitice, warty, described as cauliflower. Carcinoma wart is divided depending on location in anogenital region-Buscke-Lowenstein tumor, oral cavity, oral papillomatosis and plantar-epithelioma florida cuniculatum.
Lymphadenopathy. Invasive carcinoma in the regional lymph nodes is larger, requiring biopsy, fine needle aspiration nodes.
High-risk squamous tumors: Location on the lip and ear-high risk of metastasis -Marjolin ulcer, anogenital region -Lesions over 2 cm in diameter are associated with metastasis of 30% -Depth of invasion is associated with increased local recurrence and metastasis, tumor less than 2 mm depth rarely metastasize, and spread to more than 2-4 mm recurrence of 7%, 16% over 6 mm Differential low-tumors have a negative prognosis, with 54% recurrence -Total rate of tumor recurrence after extraction is 10-23% -Perineural invasion occurs in 2, 4%, the involvement of major nerve branches carries a high risk of recurrence, and death etastazare.