Pathogenesis of ankylosing spondylitis is incompletecunoscuta.Un number of features of the disease includingincreased serum levels of IgA and acute phase reactants,inflammatory histology and close association with HLA-B27-mediated immune mechanisms involved, so it's an autoimmunedisease. Not yet identified any particular event that might trigger the disease, but consider the possible involvement of entericbacteria.
Sacroileita initial lesion is, it consists of subchondral granulation tissue containing lymphocytes, plasma cells, mast cells,macrophages, usually condrocite.De iliac cartilage, thinner atsacred Dacite primul.Marginile sclerotic eroded joints arereplaced gradually eroded irregular regeneration andfibrocartilajului osificare.Aceste then changes are visibleradiographically.
The spinal lesion consisted of granulation tissue in the presence ofall the junction between cartilage and fibrous ring of the disc'speripheral edge fiber ring vertebral.Fibrele body are eroded andeventually replaced with bone tissue forming a bony growths calledsindesmofit beginning, developing the continue to unite the vertebral corpus.
Progression of this process gives the appearance of bamboocolumn, observed radiologically.
Other lesions are diffuse osteoporosis, the vertebrae squares.
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