Primitive lateral sclerosis
It is a very rare disease. Mainly affects adults between 30 and 50 years.
Clinically, the disease evolves with progressive spastic paresis of limbs, spastic dysarthria and dysphagia. The disease is not accompanied by fasciculations, amiotrofii or sensory disorders.
Pathologist, was a loss of large pyramidal cells and degeneration of precentral girusul corticospinale and corticobulbare projections. Peripheral motor neurons are not touched.
Disease progression is variable and can evolve slowly or aggressively forward as amyotrophic lateral sclerosis.
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