All types of muscular dystrophy are hereditary. The generesponsible for Duchenne and Becker dystrophy is transmittedthrough the mother's X chromosome. Women have two Xchromosomes, while males have one X chromosome and one Y chromosome The disease is said not to female infants as a normal gene on one X chromosome is dominant over the defective geneon chromosome X. In the other hand, women can transmit the disease in male newborns. Because boys do not inherit only one Xchromosome, they do not receive a normal gene to a counter onthe damage so that the defect occurs on chromosome X and thedisease was declared.
Dystrophin is a protein produced by muscle that helps muscle cellskeep their shape. Defective gene that lies at the origin ofDuchenne muscular dystrophy prevents the production ofdystrophin, resulting in membrane damage and necrosis (death) of muscle fibers.
Women vector (carrier) is 50% risk of transmitting disease sons.
Myotonic dystrophy is an autosomal dominant transmission. If one parent carries the gene for myotonic dystrophy, is 50% risk of transmitting the disease to children.
Other types of muscular dystrophy affecting both sexes equally.
No comments:
Post a Comment