Bowen's disease

Bowen's disease is a squamous cell carcinoma in situ with the potential for lateral expansion. Large lesions may reach several inches in diameter. Studies show an association with internal malignancy 15-70%. Patients have a spot erythematous, scaly, slowly unfolding anywhere on the mucosa. Head and neck are the most common anatomical locations.
Eritroplazia Queyrat's penis is a disease variant Bowen. It is observed only in uncircumcised men and is a form of squamous cell carcinoma in situ. Progression to invasive carcinoma may occur after a variable period of time. Characteristic are few lesions or a solitary lesion, erythematous, smooth, soft and warts or scales, involving the glans penis or adjacent mucosa.
The causes include exposure to arsenic, ultraviolet radiation, human papilloma virus. Topical treatment includes administration of 5-fluorouracil in both forms of the disease, then using a keratolytic or cryotherapy. Imiquimod cream is also used an apparently effective treatment. Surgical therapy includes simple excision, the preferred surgical treatment for small lesions in areas that are not problematic. A great way Mohs micrographic excision is having the advantage of letting the control edges 100% secure. It is also used curettage, laser ablation electrodesicarea.
For uncircumcised men the risk is likely to develop Bowen's disease, however, circumcision has been shown to decrease the risk. Chronic inflammatory dermatoses of the penis also increase risk. prognosis of patients with penis shape is excellent if the diagnosis is made early. Cure rate is 90%. And for the remaining forms of disease prognosis is excellent.
Pathogenesis and causes
Bowen's disease is a form of intraepidermal squamous cell carcinoma, which can become an invasive cancer. Form appears on the glans penis or foreskin. It is observed exclusively in uncircumcised men. Progression to invasive form can occur after a period of time.
Risk factors involved in this process include:-Chronic irritation, inflammation and infection-Urine, smegma or poor hygiene can cause chronic irritation of the area-Heat, friction and trauma-Chronic infections: human papillomavirus and herpes simplex-Immunosuppression in organ transplantationChronic exposure to ultraviolet radiation-Exposure to arsenic.