Amyotrophic lateral sclerosis
* Introduction
* Clinical
* Diagnosis
* Treatment
It is also known as Charcot's disease or Lou Gehrig's disease. It is the most common form of progressive motor neuron disease and is known as the most devastating of neurodegenerative diseases. Amyotrophic lateral sclerosis is characterized by degeneration of motor neurons of the spinal cord and motor cranial nerve, and the degeneration of pyramidal beams and cells of origin.
It is a progressive, debilitating, fatal. Walking, talking, eating, swallowing and other basic functions become more difficult over time. These conditions can cause different injury, illness and other problems.
Anatomical, disease characterized by degeneration of motor neurons both systematic central and peripheral. One can notice a pronounced degeneration of the motor horn cells of spinal previously. Lesions have been described especially in the neck swelling. Pathways are damaged and pyramidal cells, motor cranial nerves and pyramidal cells in frontal circumvolutiunea upward.
This condition has close ties with polio previous nosological chronic, with chronic spinal atrophy with chronic bulbar paralysis, as well as chronic progressive ophthalmoplegic.
Frequency of disease is 1-3/100000 individuals each year. Men are more susceptible than women. Age of onset usually ranges between 30 and 50 years but still can occur at any age. The disease progresses relentlessly, leading finally to death by paralysis of respiratory muscles. The average survival after onset is 3-5 years.
Causes
Hereditary or familial forms are exceptional. According to some authors, exogenous factors have a major role in causing disease. Among the triggers were mentioned exogenous intoxication, infection, trauma, spine, etc.. Some infectious agents can cause a similar syndrome, amyotrophic lateral sclerosis (amyotrophic lateral sclerosis side) such as syphilis, low form of lethargic encephalitis, spinal forms of encephalitis in spring.
Recent data suggest that excitotoxici neurotransmitters such as glutamate case, can cause motor neuron death by accumulation of free radicals.
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