Ankylosing Spondylitis
* Introduction
* Pathogenesis
* Causes
* Signs and symptoms
* Evolution and prognosis
* Treatment
Pathogenesis
Pathogenesis of ankylosing spondylitis is incomplete cunoscuta.Un number of features of the disease including increased serum levels of IgA and acute phase reactants, inflammatory histology and close association with HLA-B27-mediated immune mechanisms involved, so it's an autoimmune disease. Not yet identified any particular event that might trigger the disease, but consider the possible involvement of enteric bacteria.
Sacroileita initial lesion is, it consists of subchondral granulation tissue containing lymphocytes, plasma cells, mast cells, macrophages, usually condrocite.De iliac cartilage, thinner at sacred Dacite primul.Marginile sclerotic eroded joints are replaced gradually eroded irregular regeneration and fibrocartilajului osificare.Aceste then changes are visible radiographically.
The spinal lesion consisted of granulation tissue in the presence of all the junction between cartilage and fibrous ring of the disc's peripheral edge fiber ring vertebral.Fibrele body are eroded and eventually replaced with bone tissue forming a bony growths called sindesmofit beginning, developing the continue to unite the vertebral corpus. Progression of this process gives the appearance of bamboo column, observed radiologically. Other lesions are diffuse osteoporosis, the vertebrae squares.
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