Charcot-Marie-Tooth disease Treatment

Charcot-Marie-Tooth disease

    * Introduction
    * Diagnosis
    * Treatment

Treatment
Patients are only treated symptomatically. There is no treatment to stop demyelination, cure or slow down the natural disease process. Surgery is indicated for severe deformities, scoliosis. It is determined by patient age. Surgical procedures include release of plantar fascia, tendons, osteotomy and joint stabilization.
Medical therapy: It is administered analgesics, anti-inflammatory and antipyretic. Their mechanism of action is unknown, but appear to inhibit cyclooxygenase activity and prostaglandin synthesis.
Physical therapy and rehabilitation: We recommend special stretching exercises daily heel to prevent Achilles tendon shortening. It wears shoes with good ankle support. Outpatient physical therapy can assist and evaluate ortozele. Some patients may require Cirja or a walking frame in order to improve stability, but less than 5% require wheelchair.
Surgical therapy: Surgical interventions are staged. The first procedure is usually plantar release. When the heel is flexible, aggressive treatment early, delayed releasing the soft tissues need more extensive reconstructive procedures. Triple arthrodesis serves as rescue procedure for patients who have failed other procedures, as well as those with untreated fixed deformities. Children under 8 years old with slim legs and respond to clear plantar tendon transfer. Children under 12 years of rigid deformation of the medial plantar foot clearance required urgently. Spine deformities can be treated as idiopathic scoliosis.
Experimental Therapeutics: Stem cell therapy and gene transfer are the most promising forms of treatment for Charcot-Marie-Tooth disease. There were good results in antiprogesteronice therapy and vitamin C. Vitamin C reduces premature death and demyelination.
Prognosis: The prognosis for different types of the disease varies and depends on clinical severity. In general, Charcot-Marie-Tooth disease is slowly progressive muscle weakness secondary to disability and deformity. The disease does not shorten life expectancy. The loss of protective sensation distally in all four states are succeptibili patients with this disease to ulcers and heartburn, ulcers that will not heal and severe deformities of the feet bilaterally. If not worn properly ortozele for treatment can become a source of trauma and infection.