In addressing the patient history and physical examination isimportant. Family history is important because over 44% of patients have such a positive track record for similar movements.
Various laboratory studies to evaluate dystonia include bloodbiochemistry, liver function tests, ceruloplasmin level, copperblood. Computer tomography and magnetic resonance imaging ofthe brain are important in the pediatric population and can identifytumor lesions, hypoxic, or hemorrhagic. Slit-lamp eye examinationfor Kayser and cupruria ring of 24-hour urine is useful. Evaluation of genetic abnormalities and genetic counseling DYT genes areimportant for patients with onset of primary dystonia in 30 years or those who have an affected relative.
The differential diagnosis is made with the following conditions:Willson disease, Parkinson's, brain infections, brain and muscleinjuries, Huntington's disease, Leigh disease, lipid storagedisease,
Dystonia may be a clinical manifestation of many neurologicaldiseases treatable. A number of drugs can induce acute dystonia.Common drugs that are antagonists induce dopamine,haloperidol, metoclopramide, antilepticele, phenytoin,carbamazepine, valproic acid, felbamat, levodopa, adrenergicagents, amphetamines, caffeine, beta-agonists, antihistamines,tricyclic antidepressants, lithium, cimetidine, oral contraceptives,cocaine.
Functional impact of dystonia varies from barely notifiable untilsevere disability.
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