Porokeratoza

Porokeratoza

    * Introduction
    * Symptoms and Diagnosis
    * Treatment
Porokeratoza is a clonal alteration keratinization characterized by one or more atrophic patches surrounded by an annular edge blade called hyperkeratosis histologically distinctive horn. Five clinical variants are recognized porokeratozei: CALS porokeratoza's Mibelli, porokeratoza disseminated actinic superficial palmar and plantar porokeratoza disseminated porokeratoza porokeratoza linear and spotty. Also included are several other variants and the warty papular pruritic porokeratoza located on the thighs mimind psoriasis. Occasionally the patient may present several options porokeratoza co.
Keratosis lesions are brown spots, multiple or single, with different locations, ring. Are asymptomatic but can be itchy. Through exposure to the sun they become more visible. The causes include exposure to ultraviolet genetically predisposed to a patient or may occur after radiation, sunburn. The condition occurs most often in people with thin skin and light colored. Most lesions are asymptomatic. Ulcerative lesions can be described. Injuries can cause destruction of the local giant. Malignant degeneration is reported in all forms of porokeratoza, with a risk between 7-11%. Large lesions, the long and linear type shows the highest risk.
Treatment is individualized depending on lesion location, size, functional and cosmetic considerations, the risk of malignancy and patient preference. We recommend sunscreen to prevent skin cancer. Drug therapy includes various schemes and options such as topical 5-fluorouracil to induce remission in all forms of porokeratoza analogues of vitamin D3 effective topical therapy after 6 months, 5% imiquimod cream, topical and oral retinoids, which reduce the risk of malignant incienta patients with high skin cancer.
You can opt for surgical treatment options for malignant lesions in the transformation process. The practice of excision, cryotherapy, and curettage electrodesicarea. The results are available dermoabraziunea less effective, laser therapy, photodynamic therapy. Evolution of patients is generally excellent. Patients with the highest risk of skin cancer are those with immunosuppression which develops and classical linear porokeratoza Mibelli.
Pathogenesis and causes porokeratoza Clonal Hiperproliferarea atypical keratinocytes leads to the formation of horny lamellae that extend peripheral lesions and form distinctive between normal and abnormal keratinocytes. Local or systemic changes in immune function enable the development of atypical clones of keratinocytes. Heterozigozitatii loss mechanism was proposed safeguarded porokeratoza linear. There are several risk factors for development porokeratozei: genetic inheritance, ultraviolet radiation and immunosuppression. Immunosuppression may be associated with secondary porokeratoza Pathologie process as a lymphoma or HIV infection or iatrogenic immunosuppression due to immunomodulatory drugs used to prevent rejection of organ transplants or treat autoimmune disease. He established a form of autosomal dominant inheritance for all forms of porokeratoza. It is believed that exposure to ultraviolet trigger disease.
Formation of basal or squamous cell carcinoma is present in all variants porokeratoza. Palmar and plantar Porokeratoza disseminated is transmitted in an autosomal dominant manner with variable penetrance, as gained can be caused by immunosuppression or may be a cutaneous manifestation of internal malignancy.