In terms of etiological theories according to which there are morecell histiocytosis belongs Langherhans would be immune diseasesor pathology postviral installed. Experimental studies have notedthat there is a proliferation of cells Langherhans, but it is notmultiplication of neoplastic nature, so does not belong to diseasepathology, oncology.
There is a hypothesis that cell histiocytosis Langherhans (LCH)may be mediated by cytokines since their release in excess.Cytokines are soluble products secreted by lymphocytes and monocytes. By their action, legundu the specific receptors regulatecell growth and differentiation of hematopoietic cells.
If cell histiocytosis Langherhans is aberrant cell activity, cytokinesactinoeaza exaggerated and give the impression of loss of controlof this process. The cytokines involved are tumor necrosis factor(TNF-alpha) and colony growth-stimulating factor.
The nature of the viral theory of disease was issued because itknows that the system plays a role in imunoreglare mononuclear cells. Cell histiocytosis Langherhans If there aberrant immune system activity and illness can result from a viral infection that would cause the onset of reactive cell proliferation Langherhans.Through various experimental investigations excluded viral etilogianature caused by viruses such as HIV, adenoviruses,cytomegalovirus, Epstein-Barr virus, parvovirus, herpes virus andherpes virus hominis type 6.
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