Symptoms of neuroblastoma is varied. This helps the seat tumor size, stage of evolution and its extension, are also suggestive of the existence or not of metastases and their location.
The most common clinical sign is the increase in volume of the abdomen in a child with an average age of 2 years. By performing physical examination palpation of the abdomen are seen in the existence of bulky solid set of firm, whose surface has irregular edges and is painless.
Palpation of the lower edge of the liver in the coastal highlights a hipertofie sliding along the edge of it, called hepatomegaly. This occurs in infants with metastases (MTS) liver.
If neuroblastoma is exitinde the conjugation holes cause spinal compression on spinal nerve roots, installs manifestation of neurological disorders and sfincteriene.
The disease may begin with myoclonus syndrome-opsoclonii, in which the patient presents chaotic movements of eyeballs, myoclonus and ataxia.
The infant seat is located tumor frequently in the neck and thorax.There are cases where the tumor is diagnosed fortuitously during an X-ray chest. When the origin of tumor is lymph simpatico may be associated ipsilateral Horner syndrome in evolution.
Cutaneous nodules may ecchymotic child, sign suggestive of metastases in the skin. This will cause bone metastases in bone pain of high intensity. Patients showing clinical examination proptozis (eyelid closure failure) and periorbital ecchymosis also has orbital metastases.
The clinical importance and may epistaxis nasal obstruction when the tumor localization preznta rare esthesioneuroblastoma olfactory bulb.
Prolonged febrile syndrome, psycho-motor agitation, growth disorders can be smne suggest to tumor metastases in the process.Because antibodies against neural tissue to install a series of neurological events.
When the tumor originates in the adrenal medulla, neuroblastoma is secreted catecholamines can produce hypertension, other vasoactive substances likely cause secretory diarrhea.
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