Cerebral Hemorrhage of blood diseases

Cerebral Hemorrhage of blood diseases
Disorders of haemostasis, the coagulabilitate, occur in a number of congenital conditions and are won or unusual cause of intracerebral hemorrhage. These disorders can be found both in adults and the child or adolescent. At the latter occurs or primary congenital bleeding disorders, like haemophilia or afibrinogenemiei.
Intracranial bleeding in hemophiliacs occur in the subdural space and brain parenchyma around the same proportion.
Haemophilia is the cause of cerebellar hemorrhage in children and young adults in proportions varying from author to author, mortality rates ranging between 2.3 and 13%.  
Among the risk factors for bleeding in hemophiliacs mentions young age, trauma, and disease severity. The appearance of cerebral hemorrhage after head trauma occurs sometimes immediately, sometimes every few days. On the merits haemophilic intraventricular bleeding may occur or may occur spinal epidural hematoma.
Coagulabilitate secondary disorders occur in a number of pathological conditions of unknown cause, or the immunopathological background of cancer. Intracerebral hemorrhage may be the final moment of a leukemia or other lymphoproliferative diseases. In terms of leukemia, bleeding occurs more frequently in certain forms of acute leukemia and may occur both in brain parenchyma, and subarachnoid or subdural space. Bleeding can be multifocal, may be associated with massive bleeding and petechiae. They are located predominantly in white matter.
- Thrombocytopenia is a substrate that can trigger intracerebral hemorrhage. Thrombocytopenia are found in diseases like leukemia, myeloproliferative disorders, aplastic anemia or various forms of idiopathic thrombocytopenia. Bleeding occurs when platelet count is below 20.000/mm3
- Idiopathic thrombocytopenic purpura is the most common cause of thrombocytopenia in children. Severe bleeding and brain hemorrhage occurring in 1-2% of children under the crimson when platelets are 10.000/mm3. It locates in cerebellar white matter. 
 - Thrombotic thrombocytopenic purpura occurs in young women and is characterized by thrombocytopenia, microangiopathic hemolytic anemia, renal impairment, fever, diffuse or focal neurological signs and cerebral hemorrhage.
- Iatrogenic thrombocytopenia occur following the administration of certain drugs. Heparin used in the treatment of acute myocardial infarction (MI), or thrombophlebitis of cerebral infarction may induce thrombocytopenia in 5-10% of treated cases and in 10% of these cases can and cerebral hemorrhage. Other drugs that may induce tromocitopenie be found: thiazides, quinidine, estrogens, cytotoxic, furosemide, chloramphenicol, phenylbutazone, aspirin, acetaminophen, alfametildopa, digoxin, carbamazepine, tolbutamide, gold salts.
- Hipoprotrombinemia may be associated with intracerebral hemorrhage in newborns, in states of malnutrition, malabsorption syndromes, severe liver disease, high doses of vitamin E in systemic lupus erythematosus (SLE) antibody AL, as in the administration of anticoagulants , salicylates, broad-spectrum antibiotics and hydantoin. Administration of L-asparaginase can cause a syndrome with hypofibrinogenemia trigger brain haemorrhage.
- Thrombocythemia is characterized by recurrent hemorrhage preceded by or associated with venous thrombosis. Patients have splenomegaly, leukocytosis, anemia and an increased number of platelets. Intracerebral hemorrhage (HC) but rarely occurs in such cases.
- Multiple myeloma is rarely associated with HC. Paraproteinemic accumulation leads to impaired hemostasis. HC in multiple myeloma can be seen as a preterminal event and is found only at autopsy.
- Anemia drepanocitara - HC complications occur rarely. Children are more prone to bleeding.
- Polycythemia vera may be complicated and sometimes with HC, or subarahnoid subdural bleeding. Bleeding mechanism would probably be poor platelet function, lack of clot formation, turgor, veins and capillaries.
- Disseminated intravascular coagulation (DIC) occurs against a backdrop of severe systemic disorders as infections, malignancies, obstetrical complications, shock, trauma, transfusions, kidney and liver diseases. In the cerebellum can meet petechial hemorrhage or microvascular thrombi. There were reported cases of HC have evolved into massive exitus. HC can be multiple and tend to be in the cortex.