Lentigo

Lentigo or plural lentiginoza pigmented macula is a small, well circumscribed surrounded by normal-looking skin. Histologically includes hyperplasia of epidermis and increased basal layer pigmentation. I present a variable number of melanocytes, which are increased in number but do not form nests. Lentiginoza poate evolua incet dea lungul anilor sau poate erupe si apare relativ rapid. Pigmentarea poate fi omogena sau variata cu o culoare variind de la maro pina la negru. Lentiginoza may evolve slowly over years or breaks and is relatively fast. Pigmentation may be homogeneous or varied with a color ranging from brown to black up.

Exista multiple varietati etiologice si clinice. There are multiple etiological and clinical varieties. Diferenta dintre formele de lentigo si alte leziuni melanocitice (nevi, melanom ) si rolul sau ca marker pentru leziunile ultravioletelor si sindroamele sistemice este de importanta majora. The difference between other forms of lentigo melanocitice lesions (nevi, melanoma ) and its role as a marker for ultraviolet damage and systemic syndromes is of major importance.
Lentiginoza solara se observa la peste 90% dintre persoanele albe peste 60 de ani si 20% dintre albii peste 35 de ani. Lentiginoza psoralen UV-A se noteaza la jumatate dintre persoanele cu psoriazis care necesita terapie cu UV-A pentru cel putin 5 ani. Lentigo simplex este cea mai comuna forma de lentigo dar frecventa sa nu a fost inca determinata. Solar Lentiginoza observed in more than 90% of white people over 60 years and 20% of whites over 35 years. Lentiginoza psoralen UV-A is noted in half of people with psoriasis who require therapy with UV-A for at least five years . lentigo simplex is the most common form of lentigo but its frequency has not yet been determined.

Lentigo este benigna prin natura sa, totusi unele sunt asociate cu anomalii sistemice in plus fata de manifestarile dermatologice. Lentiginoza solara este mai abundenta la albii cu piele subtire decit la persoanele cu piele mai inchisa la cuoare, deoarece boala este foarte rara acestia avind o cantitate crescuta natural de pigment care confera un grad de fotoprotectie. Lentiginoza ereditara poate apare la negrii, mai ales la mulatri si roscati. Lentigo is benign in nature, though some are associated with systemic anomalies in addition to skin manifestations. Lentiginoza sunlight is more abundant in white with thin skin than people with darker skin cuoare as having the disease is very rare these amounts Increased natural pigment that gives a degree of photoprotection. Lentiginoza hereditary may occur in blacks, especially in mulatri and redheads. Efelidele, lentiginoza la UV-A psoralen, lentiginoza la solarul artificial, lentiginoza vulvara, lentiginoza in pete de cerneala, maculele melanotice orale si labiale si sindromul Laugier-Hunziker sunt frecvente la persoanele cu piele alba. Efelidele, lentiginoza psoralen UV-A, lentiginoza to artificial tanning, lentiginoza vulvar, lentiginoza in ink stains, oral and labial macules melanotice Laugier-Hunziker syndrome are common in people with white skin. Lentiginoza in pete de cerneala apare la persoanele cu stramosi celtici. Lentiginoza ink stains occur in people with Celtic ancestry.

Criochirurgia este un tratament simplu pentru lentiginoza izolata. Cryosurgery is a simple treatment for lentiginoza isolated. Aceasta procedura este de succes datorita succeptibilitatii melanocitelor de a ingheta la nitrogen lichid . This procedure is successful because succeptibilitatii melanocytes in liquid nitrogen to freeze. Laserele sunt eficiente in tratamentul lentiginozelor variate. Cremele topice noninvazive sunt folosite de asemeni. Lasers are effective in treating various lentiginozelor. Noninvasive topical creams are also used. Dupa citeva luni de aplicare creme cu tretinoin si cu hidroquinona pot albi lentigo. Peelingul chimic profund poate fi mai eficient criochirurgiei. After several months of applying tretinoin cream and white can hidroquinona lentigo. Deep chemical peeling may be more effective criochirurgiei.

Patogenie si cauze pentru lentigo Pathogenesis and causes of lentigo

In functie de tipul de lentigo prezent, o leziune solitara sau multipla poate apare oriunde pe corp. Depending on the type of lentigo now, a solitary or multiple lesions can occur anywhere on the body. Unele lentigo au menifestari sistemice asociate care acompaniaza pe cele dermatologice. Some lentigo were associated systemic manifestations would accompany on the skin. Unele studii sugereaza ca lentigo solar poate fi indus de efectul mutageni al expunerii repetate la ultravioletele A conducind la modificari caracteristici ale producerii de melanina. Some studies suggest that solar lentigo can be induced by mutagenic effect of repeated exposure to ultraviolet A, leading to changes in characteristics of the production of melanin.

Cauza formarii lentiginozei depinde de tipul de leziune. Case lentiginozei formation depends on the type of lesion. Cauza pentru lentigo simplex este necunoscuta. The cause is unknown lentigo simplex. Exista cazuri care au raportat aparitia acesteia dupa aplicarea topica de tacrolimus pentru dermatita atopica . There are cases that have reported its appearance after topical application of tacrolimus for atopic dermatitis . Lentigo solar si lentigo in pete de cerneala sunt asociate cu expunerea la soare la persoanele cu piele alba. Solar lentigo and lentigo in ink stains are associated with sun exposure in people with white skin. Lentiginoza la psoralen UV-A este asociata cu terapia cu UV-A la pacientii cu psoriazis. Lentiginoza to psoralen UV-A is associated with UV-A therapy in patients with psoriasis. Lentigo de iradiere este determinata de o iradiere cu doza crescuta. Factori genetici pot fi implicati in alte forme de lentiginoza sindromul LEOPARD, sindromul Peutz-Jeghers si lentiginoza ereditara. Radiation lentigo is determined by a high dose irradiation. Genetic factors may be involved in other forms of lentiginoza LEOPARD syndrome, Peutz-Jeghers syndrome and hereditary lentiginoza.