Enteropathy with loss of protein

Enteropathy with loss of protein

    * Introduction
    * Causes
    * Signs and symptoms
    * Diagnosis
    * Treatment
Enteropathy with loss of protein is a clinical condition that occurs in some gastrointestinal diseases and causes excessive loss of serum proteins through the gastrointestinal tract. Daily normal plasma protein losses are 1-2% of plasma and consist of damaged enterocytes and pancreatic and biliary secretions. Normal albumin loss through the digestive tract are the degraded 2-15% of total albumin in the body. In patients with protein losing enteropathy with loss of albumin can reach 60%.
Clinical excessive albumin loss is manifested by the appearance of edema, conditions predisposing to infection and bleeding. Therapeutic control of enteropathy with protein loss involves the treatment of disease. Serum protein levels reflect the balance between protein synthesis, metabolism and protein loss. Enteropathy with loss of protein is characterized through a loss of protein through the gut more than synthesis, leading to hypoproteinemia.
The disease is not a single disease but an atypical manifestation of a host of other diseases.
Pathogenesis
Pathophysiology of this disease is directly related to excessive removal of plasma proteins in the lumen of the gastrointestinal tract. Enteropathy with protein loss mechanisms include lymphatic obstruction, diseases of the intestinal mucosa with esroziuni formation, ulceration, or increased permeability to protein as a result of infringement of cellular or cell death. Proteins in the gastrointestinal tract amino acid constituents are metabolized by enzymes in the stomach, the pancreatic and intestinal juice and then reabsorbed. When the rate of protein loss through the gastrointestinal tract increases the body's ability to synthesize new proteins is outdated and develop hypoproteinemia.
Enteropathy with loss of protein may occur in some tumors, ischemia, or inflammation of the colon. Adaptive changes of endogenous plasma protein synthesis can be used to offset excessive loss of protein.