Transverse myelitis

Transverse myelitis Transverse myelitis is presented as an inflammatory reaction of the spinal cord. Transverse myelitis may be acute, subacute and chronic. The syndrome manifests as either a bone marrow or bone marrow as the clinical syndrome in encephalomyelitis. Most often the signs are located strictly to the marrow. Transverse myelitis may be part of the array of diseases like multiple sclerosis, Devic's disease, systemic lupus erythematosus, sarcoidosis, collagen vascular disease, Sjogren's syndrome and Behcet's disease.
Causes Transverse myelitis is associated with a history of infection or recent vaccination. In most cases, the infectious agent is virus. The disease can result from infection with influenza virus, Epstein-Barr virus or cytomegalovirus, or may be the result of eruptive diseases like measles, chickenpox, rubella, mumps. May occur during anti-rabies treatment, following a microbial infection (Mycoplasma) or after infection Lueta. Transverse myelitis as the patient begins to heal appears after an infection, but infectious agents have been identified in the nervous system of infected persons. From this it follows that the disease is an autoimmune disorder triggered by infection.
Clinical Acute form is manifested by the general signs of infectious, high temperature, pain focused nature, and posterior cervical meningiene signs. Neurological signs are installed within a few days, resulting in a syndrome of medullary transverse section. Various combinations appear paresthesia, sensitivity problems, motor paresis and sphincter disorders. Tendon reflexes are abolished. Pressure arising from the early days and tend to expand in depth and surface, can result in necrosis and denudation during film regions. If evolution is favorable, the symptoms disappear after 2-3 weeks, muscle contractions occur and Babinski sign, tendon reflexes reappear may become exaggerated. Paralysis persistent areflexia indicate necrosis of multiple spinal segments. In mild forms can only mild sensory symptoms. Severe forms of the syndrome evolves functional spinal cross sectioning. In Landry's ascending form and upper limbs are affected and paralysis of respiratory muscles occurs, and evolution is often debilitating to exitus. Subacute and chronic forms have a slow, manifesting as a chronic spastic parapareze with sphincter disturbances and no sensitivity problems. Diagnostic images in MRI (magnetic resonance imaging) show a variable marrow edemas emerge. Interruption of the blood-brain barrier in acute cases associated with perivenous inflammation translates into MRI images by increasing contrast. Required to be made a brain MRI to determine if an attack is somewhat transverse myelitis initial multiple sclerosis. Transverse myelitis in cerebrospinal fluid often presents with predominant Pleocytosis mononuclei, is slightly elevated protein level.
Treatment Mild forms resolve themselves. In the case of moderate and severe methylprednisolone is administered intravenously, followed by administration of oral prednisone. Methylprednisolone is administered in amount of 250 mg dissolved in 250 ml 5% glucose solution and administered over a period of 1-2 hours iv (intravenously) for 3 days. After the 3 days passed after administration of oral prednisone 1 mg / kg / day in single dose in the morning for the next 13 days. After the 13 days, prednisone is administered for one day in the amount of 20 mg / day, then for the next three days is administered 10 mg / day prednisone.