Androgens (male sex hormones) are secreted by Leydig cells inthe testes, testosterone and form the adrenal (the periphery of the adrenal gland).
Starting at the age of 30, testosterone levels diminish by 10% ineach decade of life. In the normal functioning of the male hormone system, the bulk of testosterone (about 98%) is related to twocomponents of blood: albumin and globulin - and carry you toparticipate in the regulation. The remaining 2% is free orbioavailable testosterone.
Although testosterone levels decrease progressively with the age,he remains in a range of values considered normal. Free testosterone level falls very much between 40 and 70 years. Thesechanges are important, but always remained within normal limits.For this reason, it is not known what clinical significance isdecreasing androgen levels. Sexual dysfunction can not beascribed only to low testosterone levels. As in most men of acertain age, testosterone levels remain within a range considered normal, it may not be a factor contributing to erectile dysfunction.
The middle-aged men was a progressive decrease in the numberof Leydig cells and Sertoli cell function impairment - two possiblecauses of the general decline of androgen levels. Unlike ovaries,testes involution function is not accompanied by a halt to activity,but a progressive change.
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