Felty Syndrome - Diagnosis

Laboratory studies:
-Full blood count to determine differential granulocytopenia
thrombocytopenia, anemia with hypersplenism
anemia of chronic disease, inflammatory disease result frombackground
-moderate increase in transaminases and alkaline phosphatase
High-titer rheumatoid factor
-antinuclear antibodies, and antineutrofile antihistone
erythrocyte-sedimentation rate and elevated serumimmunoglobulin levels
-this cryoglobulins.

Imaging Studies:
Scanning scintigraphy, ultrasound or CT scan can assess the presence and extension of splenomegaly and response to therapy.
Bone marrow aspiration and biopsy are important to rule outleukemia syndrome. Bone marrow of patients with the syndromeand normal megakaryocytes Flety show off myeloid hyperplasiadevelopment in immature cell types.
The differential diagnosis is made ​​with the following conditions:cirrhosis, non-Hodgkin's lymphoma, systemic lupus erythematosus,tuberculosis, myeloproliferative diseases, sarcoidosis, Sjogren'ssyndrome, chronic infection, drug reaction, rheumatologicdiseases, infiltrative diseases, HIV infection, pseudo-Feltysyndrome.