Felty Syndrome - Treatment

The syndrome can be controlled Flety rheumatoid arthritis.Immunosuppressive therapy for this improves granulocytopenia and splenomegaly, reflecting the fact that Flety syndrome is immune mediated disease. Most traditional medicines are also useful in rheumatoid arthritis Flety syndrome.
History sometime patients were treated with gold salts before the advent of methotrexate, with poor response to therapy.Methotrexate acts more rapidly than gold and is the preferred agent for treating rheumatoid arthritis Rheumatology. It has become the drug of choice in therapy. If urgent correction of neutropenia is not required to use this drug in treating first the Flety syndrome. It is combined with folic acid to minimize adverse effects. The beneficial effects of methotrexate are visible only after 4-8 weeks.
Limits the potential for leukemia using cyclophosphamide.Penicillamine is rarely used because of side effects. Therapy of choice is never Flety syndrome. Etanercept, adalimumab and infliximab are never prescribed for Felty syndrome. These agents work by blocking the effects of TNF alpha. They are very effective in treating rheumatoid arthritis and control, although experience is limited Flety syndrome. Intravenous immunoglobulin treatment does not show success. Granulopoietic growth factor administered recombinant granulocyte number is growing rapidly in people with life-threatening infections.
At high doses, corticosteroids increase the number of granulocytes by demarginalizare. This effect does not persist in the transition to low dose. Empirical administration of high doses of intravenous methyl-prednisolone Flety syndrome are prescribed, but the effect is limited by time. Long-term use of corticosteroids increases the risk for infection. Corticosteroids are second-line therapy.
Surgical therapy:Splenectomy is recommended only in patients with severe disease who show no improvement with medical therapy and experiencing severe recurrent infections. Less hemolysis extrinsic or recurrent skin ulcers may indicate splenectomy. Granulocytopenia recurs in 25% of patients with splenectomy.
Prognosis:Severe infections can lead to death. Spontaneous remission of the syndrome may occur. There is an increased risk of cancer in Flety syndrome. Non-Hodgkin's lymphoma is 12 times more frequently.The risk for developing leukemia is increased for the first 5 years after hospitalization.