Diffuse disease with Lewy bodies

Diffuse disease with Lewy bodies

Diffuse disease with Lewy bodies is characterized by neuronal cytoplasmic inclusions are PAS positive.



Typically, Lewy bodies are found in the cortex of patients with Parkinson's disease and patients with dementia. In patients who have only those features that pathological condition is called "diffuse Lewy bodies disease. The condition is often difficult to distinguish from Parkinson's disease with dementia and Alzheimer's disease.



There are patients who have been detected in brain amyloid plaques, in addition to Lewy bodies. In them, the disease called "Alzheimer's disease with diffuse Lewy type.



In terms of clinical symptoms does not differ much from that of patients with dementia, presenting them in addition to some elements of Parkinson's disease such as rigidity and intentional tremor.



Other new elements in clinic patients with Lewy bodies are changes in behavior, cognitive function and alterations of consciousness, visual or auditory illusions and hallucinations. These symptoms may lend itself to confusion with delirium, but with Lewy bodies disease symptoms persist for a long time.



A feature of these patients is that they are particularly sensitive to neuroleptic drugs and benzodiazepines, even in standard doses administered.



There is no specific treatment.