Fibrosarcoma - Signs and symptoms

Fibrosarcoma may be diagnosed in patients of all ages but occurs most frequently in the fourth decade of life. Represents only 10% of musculoskeletal sarcomas and less than 5% of primary tumors of bone. It is more common in men than in women. It is located in the lower extremities, especially the tibia and femur.Fibrosarcoma of soft tissues usually affects a wider variety of patients from that of bone, with an average age of 35-45 years.Appears on facial soft tissues of the posterior thigh and knee. It is a large mass, painless deep fascia with bad edges defined. There is also a form of infantile fibrosarcoma. Unlike the adult has an excellent prognosis, even in front of metastasis at presentation, when treated with chemo therapy and resection.
Sarcomas involving the bones often present with pain and swelling after a long period of evolution. They can grow enough to threaten the structural integrity of bone and cause pathological fractures. In general, lesions involving more than 50% of the bone cortex, which are more than 2 cm in diameter or involving middle area of ​​the femur are associated with increased risk of fracture. Previous history of bone infarction, radiation or other risk factors suggests secondary fibrosarcoma.
Soft tissue sarcomas present as painless masses, smaller than those involving bone. As it develops deep facia muscle can become very large before diagnosis. Most injuries occur around the knee, proximal femur and proximal arm or thigh region. The physical masses are nonspecific and appear as firm, fixed area of ​​localized tenderness. Neurological or vascular changes are delayed and show extensive damage to the tumor.The clinical picture of fibrosarcoma may include:-Local pain, local swelling-Palpation a firm mass beneath the skin overlying a bone or-Fracture, damage to normal ambulatiei-Neurological symptoms, gastrointestinal bleedingUrinary urgency, pelvic fibrosarcoameleUrinary obstruction in pelvic-fibrosarcoamele.
Disease progression:Metastases occur late in the evolution fibrosarcoamelor. Their lungs are the main location, if it develops in the extremities. Once the lung metastases appeared chances of survival decreased significantly. If included at all stages of primary fibrosarcoma of bone disease has a negative prognosis osteosarcoma compared with 5-year survival of 65%. In poorly differentiated fibrosarcoma 10-year survival below 30%. Secondary fibrosarcoma is associated with a poor prognosis with survival 10 years less than 10%. For congenital fibrosarcoma of bone in children, the prognosis is much better survival rate of 50%.