Aclorhidria and hypochlorhydria

Aclorhidria and hypochlorhydria

    * Introduction
    * Causes
    * Signs and symptoms
    * Diagnosis
    * Treatment
Loss or reduction of gastric acid secretion is known as hypochlorhydria aclorhidrie, respectively. Gastric hydrochloric acid secretion is an important step in the process of digestion. Its lack of serious disorders cause over the entire digestive tract.
Your stomach needs an acidic environment for: Protein-digesting ingested -For the normal gastric emptying, gastroesophageal reflux altered forcing Stomach-to sterilize and kill bacteria that can be ingested -Is necessary for the absorption of some micronutrients calcium, magnesium, zinc, iron, selenium etc..
As grown old ability to produce stomach acid diminish. Some people do not produce gastric acid due to certain allergic diseases such as gastritis secondary to food intolerance, chronic gastritis with Helicobacter pylori, pernicious anemia, gastric cancer or unknown causes.
Aclorhidria varied and may cause severe digestive disorders, malnutrition, megaloblastic anemia and increases the risk of developing gastric cancer.
Short term treatment of acid supplementation. The known association of asthma in children aclorhidria and hypochlorhydria. Several clinical conditions were associated with mortality and morbidity aclorhidria growing up. Typically has been associated with gastric cancer, hip fracture and bacterial overpopulation.
Pathogenesis
Gastric acid secretion is dependent on the functioning of cells oxintice cells called parietal cells. Parietal cells are present predominantly in the gastric body and fundus. They are responsible for secretion of hydrochloric acid and intrinsic factor. Parietal cells shows large mitochondria, microvili shorts and a cytoplasmic canalicular system in contact with a lumen. Pump discharge is responsible for H / K-ATPase apical membrane microvilozitara.
Parietal cell dysfunction in clinical conditions can be induced by the formation of Ac anti parietal, abnormal secretion of hormones, chronic infection with Helicobacter pylori, medications that inhibit the pump function of H / K-ATPase. Major surgery are leading to aclorhidrie bypass Roux-en Y and antrectomia with vagotomy. Mucolipidoza Patients with type IV, autosomal recessive storage disease can be constitutional aclorhidrici.
Recently we have demonstrated an enzyme involved in the pathogenesis aclorhidriei-Ezrin. One of the characteristics of parietal cells is abundant expression of Ezrin, which is concentrated in layers actinic subapicale. Thus it was speculated that Ezrin is a function of the key factors that control gastric acid secretion.