Morf - localized Scleroderma

Morf - localized Scleroderma

    * Introduction
    * Signs and symptoms
    * Diagnosis
    * Treatment
Morf also known as localized scleroderma is a disease characterized by deposition of excess collagen, leading to thickening of the dermis, subcutaneous tissue, or both. Morpheme is classified boards generalized linear su root subtypes according to clinical presentation and the depth of tissue involvement. Unlike systemic scelroza morpheme shows no sclerodactilie, Raynaud's phenomenon and internal organ damage. There is also a variant called morpheme shallow spots characterized by hypo or hyperpigmentation of the skin without mercy.
Morphea incidence is estimated at 25 million persons aczuri a year. Actual incidence is higher because cases not present at the Maedi. Two thirds of adults presenting with morphea plaque lesions, variants of generalized deep linieare counting for over 10% of cases. Over half of the cases of morphea occurring in pediatric patients. Morphea is developing typically benign, self-limiting. Survival rates for patients with morphea are different from those of the general population. Yet deep linear subtypes can cause significant morbidity, especially in children when interfering with growth. Joint contractures, limb length discrepancies and prominent facial atrophy cause substantial disability and deformity in a quarter of patients. Neurological and ophthalmological manifestations may occur in patients with craniofacial injuries. Such complications are more common in pediatric cases.
The cause of morphea is unknown. Different subtypes of the disease coexist in the same patient. I complained trauma, infection or vaccination, radiotherapy and genetic factors. There are no definitive treatments for morphea. Although some show benefits schemes are made less controlled trials.
Therapy in general wants to reduce inflammatory activity in early damage, aviind more successful than attempts to dimuna sclerosis of well-established lesions. Use corticosteroids, hydroxychloroquine, immunomodulatory therapy with ultraviolet A plastic surgery can help correct deformities.
Pathogenesis and causes
Overproduction of collagen by fibroblasts in diseased tissue is common in all forms of morphea, although the mechanism by which fibroblasts are activated is unknown. The proposed factors endothelial cell injury, inflammation and immune activation and disruption of collagen production. An autoimmune etiology is encouraged by the presence of autoantibodies. The cause of morphea is unknown. Investigations have revealed a consistent causative factor.
Putative factors include: -Radiation-morpheme can occur at a high-voltage radiation therapy for breast cancer or other malignancies, develop at a month or up to 20 years -Infection or vaccination-infection with Epstein-Barr virus, varicella, smallpox, borreliosis -Morpheme-like lesions have been reported after BCG vaccination and tetanus -Trauma, some patients reported a history of trauma preceding the focal disease Some cases family-morphea have been reported, there was described an association with HLA.