Thursday, June 16, 2011

Juvenile dermatomyositis (DMJ) - Evolution and prognosis

The evolution of juvenile dermatomiozitei not noticed a correlation between the severity of onset, sex and age of the patient.
This HLA antigen does not influence prognosis. Remissions and exacerbations are common disease.

Healing occurs in 50% of cases. Untreated cases progress to exitus in 40% of patients. Symptoms such as gastrointestinal ulcers, causing bleeding or perforationhas a fatal outcome.

Dermatomiozitei juvenile prognosis is better than the adult form.
Negative prognostic factors are: asociereea other collagen diseases, the establishment of late treatment, inadequate doses of prednisone.
Maximum improvement is achieved in the first 3 years following drug therapy. Patientswho survive one year with a long clinical course.

In the disease interstitial calcinosis is installed in the muscles and subcutaneous tissues, over 50% of patients after two years of passing by the disease. The presence of calcification is not related to metabolic disorder phosphocalcic, which is not affectedin juvenile dermatomyositis. These calcium deposits may ulcerate spontaneously and cause scarring. Heterotopic calcifications are of repairing a sign of evolution and not aserious disease.

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