Thursday, June 23, 2011

Langerhans cell histiocytosis - Prognostic

Prognosis depends on patient age and number of affected organs.
Are considered good prognostic factors unique location and greatage of the patient.
Prognosis factors are age and low-sugar baby, this multipleorganic dysfunction multisystem injuries. It requires rigoroussupervision of children between 1-6 months in order to capture theextension of lesions and other organs. For this purpose areinvestigations such as blood counts, liver function, urine osmolarity,lung and bone X-rays, dental X-rays, computed tomography (CT).

Single bone lesions are likely benign and will regressspontaneously within weeks, months or even years.

Depending on the clinical disease can be installed and latesequelae. They show a high aggression and occur inapproximately 30-50% of cases. The most common sequelae are:diabetes insipidus, growth disorders in height, orthopedicsequelae, neurological disorders with impaired intellectualcapacity.
Treatment with etoposide, topoisomerase inhibitors lead toneoplastic diseases side.

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