Thursday, June 23, 2011

Langerhans cell histiocytosis

Histiocytosis is a common term that defines a number of diseases of the reticuloendothelial system. Its cells originate in bone marrowpromonocitele mononuclear phagocyte system forming. Promoterswill give rise to two distinct cell lines: on the one hand, a cell linewith a role in phagocytosis, the Sun included peripheral monocytesand tissue macrophages that develop from histiocite called, on the other hand will rise a cell line made of antigen presenting cells, which is a cell population with no role in phagocytosis.

Proliferation of Langerhans cells neoncologica cause diseasespecialist literartura known as the cell histiocytosis Langherhans.

Histiocitele Langherhans arise from this population represented by the dendritic cell line. Specialized cells is a central core containingtwo nucleoli, pale, irregularly shaped, lobe, chromatin is dispersedand the cytoplasm eosinophilia. Cell nucleus is covered by amembrane Langherhans thin presenting intussusception.

These cells are found in the skin, forming a protective barrier cell.Due to the characteristics histiologice, Langherhans cells can be identified by optical microscopy. The specific characteristics andalso in terms of histochemical, and immunologic.

Dendritic cells are Langherhans type ATPase positive. They contain in their cytoplasm a protein called S100 nervous systemand alpha-manozidaza.

Using electron microscopy revealed a marker was represented bystructural Birbeck granules. These are some cytoplasmicorganelles with a tubular aspect, wall and formation pentalaminaridilated terminal giving the appearance of "tennis racket". Out all ofdendritic cells containing Birbeck granules in the cytoplasm themthese.

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